Crystallization - Syrris

Crystallization

Crystallization is defined as a process by which a chemical is converted from a liquid solution into a solid crystalline state. Syrris systems offer a range of solutions to the problem of crystallization monitoring and control:

Monitoring

Turbidity probe – see the Atlas Turbidity System

FBRM probe – all Atlas systems can be integrated with the Lasentec FBRM probe for particle size analysis

Control

Automation – Intelligent solvent additions and temperature control are made easy with the Atlas Softwareallowing easy metastable zone analysis

Sonocrystallization – crystallization with narrow particle size distribution and polymorph control – See the Sonocrystallisation page or the Atlas Sonolab system

Flow chemistry – Excellent control of mixing and temperature leads to narrow particle size distribution. See the Flow Chemistry page.

• Crystallization is the most common method of formation of pharmaceutical solids
• Usually aim to achieve goals of high purity and high yield by solely using controlled cooling crystallizations
• Almost all chemical processes utilise at least one crystallization step (either as key separation mechanism or final product engineering)

• Crystallization processes are poorly understood and are difficult to control
• Control of nucleation difficult but is the key to process control
• Physical form dictates drug product quality and effectiveness
• Process robustness governs process productivity and economics

Syrris products offer a range of solutions to the problem of crystallization control and monitoring.

• Excellent temperature control using sophisticated PID temperature control
• Metastable zone width determination
• Crystallize along a turbidity ramp
• Complete control of nucleation
• Improved polymorph selectivity
• Achieve extremely narrow particle distribution
• Reproducibility
• Seamless scale up to pilot plant and manufacturing
• Easy to use drag and drop software

See the Atlas Turbidity system or Atlas Sonocrystallisation system page now for more information.

For more information about crystallisation, please contact us