Formulations - Syrris

Formulations

The study of formulations, whether of industrial chemicals, pharmaceutics or household materials is vital to ensuring that when a bottle, tin or spray is opened, the material which emerges is the same as the material intended.

Flow chemistry in formulation studies

Several companies and academic groups have started to use flow chemistry as a way to study different aspects of the formulations process. Two main areas are being investigated at the moment.

Forced degradation

Flow reactors offer rapid, very accurate sample heating and can access temperatures only available in pressurised systems. Forced degradation studies utilise this accurate control of temperature, paired with the ability to accelerate decomposition processes beyond their natural rate to investigate the kinetics of the process. This can predict shelf-life in a fraction the time in an automated fashion.

Log P

Studies of LogP (material partitioning) between two phases are important for stabilised super-saturated solutions and determination of relative solubilities.

Using FLLEX (Syrris Flow Liquid Liquid EXtraction system), materials can be mixed with two immiscible liquids, time allowed for partitioning and then separated to determine the partition co-efficient.

For more information about this application, please contact us