Africa Synthesis and Analysis System - Syrris - HPLC Analysis
Synthesis and Analysis (SA) System


The Synthesis and Analysis (SA) System has all the functionality of the 4 Channel Synthesis System but also enables each reaction to be automatically analysed by HPLC.
The Synthesis and Analysis (SA) System is ideal for use in the following applications:
- Medicinal chemistry
- Method development (semi automated) - Process chemistry
- Reaction optimisation (semi automated)
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Specification
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4 Syringe Pumps: |
Flow rate 2.5µl to 2.5ml/min with pressure sensors and automatic over-pressure shutdown |
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4 Pressurized Input Bottles: |
Regulated 1 bar Nitrogen or Argon is supplied to up to 4 bottles, eliminating cavitation and bubble formation and allowing the use of air sensitive reagents (requires laboratory gas supply). |
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4 Manual Injection Loops and Valves: |
1ml, 5ml or 10ml loops |
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Automatic Reagent Injection: |
The RIM allows reagents stored on the robot deck to be automatically aspirated and loaded into one of 4 injection loops. The robot has a coaxial needle allowing the use of air sensitive reagents in vials. All timings are automatically managed, even for complex, multi-reactor systems. Samples are pre-pressurized before injection into the flowing stream. |
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Chemical Resistance: |
All wetted parts are glass, PTFE or other similar fluoropolymer. |
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2 Temperature Controlled Microreactor Positions: |
The Africa Heater/Cooler has two reaction positions, each of which can be factory set to either:
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Reaction Sampling: |
The Sampler and dilutor takes a 5µl sample from the flowing stream, dilutes it by up to 250 fold and injects it onto an analytical system e.g. HPLC, LCMS, UPLC etc. |
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HPLC Analysis: |
The Africa HPLC allows integrated synthesis conditions an HPLC traces. |
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Automation: |
The Africa software allows an almost unlimited number of reactor configurations and automates the entire process. Only “chemist friendly” data such as volumes, times and temperatures need to be added – no need to deal with flow rates if you don’t want to. The timings of all events such as pumps starting, injections, collections etc. are all automatically calculated and performed automatically. |
Parts
The Synthesis and Analysis (SA) System contains the following modules, click on the part number for more information:


