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Flow Products Asia Flow Chemistry
Asia Flow Chemistry - Syrris - The Future of Flow Chemistry
Asia Flow Chemistry
Above: Asia 110 System A robust, totally chemically resistant microreactor system for solution phase flow chemistry. Cool to -15°C or superheat reactions up to +150°C and 300psi.
Right: Asia 320 System Fully automated collection of multiple, multi-step reactions in solution or solid phase. Cool to -15°C or superheat up to 250°C. Vary reaction time, flow ratios and temperatures automatically. Perfectly suited to process optimization and then scale up from mg to kg.
Asia is a revolutionary range of advanced flow chemistry products from Syrris. It has been designed by chemists for chemists to enable the widest variety of chemical reactions and ultimate ease of use. The proprietary technology allows automated experiments with or without a PC.
Asia offers maximum chemical resistance with an extensive range of temperatures, pressures, and reaction times on scales from mg to kg.
Watch the Asia Flow Chemistry Systems video [see more videos...]
Syrris has won a prestigious R&D 100 Award for Asia
The R&D 100 Awards are a benchmark of excellence, and this award for 2012 recognizes the significance of Syrris' Asia flow chemistry system.
Asia Flow Chemistry Systems
Asia offers a variety of flow chemistry modules and systems making it ideal for both beginners with modest budgets and experts who demand the utmost functionality.
Syrris has pre-configured some systems for certain types of chemistry, please click on one of the images below to find out more.
Asia 1-series flow chemistry systems are operated manually. Asia 2-series systems can automatically perform one experiment at a time and are an ideal introduction to the world of flow synthesis.
Asia 3-series flow chemistry systems can automatically perform process optimization. Click here to find out more.
For manually operated flow chemistry, the Asia 1-series
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For automation of one flow experiment, the Asia 2-series
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For full automation of multiple flow chemistry reactions, ideal for Process Optimization, the Asia 3-series.
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Asia Flow Chemistry Benefits
- Perform a wider range of chemistries
- Flexible to meet chemist needs (and budget)
- Integration of synthesis, work-up and analysis
- Safer and cleaner reactions
- More reactions in less time
- Maximum chemical resistance
- Ideal for synthesis, rapid optimization and scale-up
- Robust and easy to use
Asia Specifications
- Reactor temperature: -15°C to +250°C
- Liquid phase reactor volumes: 62.5μl, 250μl, 1ml, 4ml, 16ml
- Solid phase reactor volumes: 0.7ml, 2.4ml, 5.6ml, 12ml
- Pressure: 0 – 20bar (300psi)
- Flow rate: 1μl/min – 10ml/min per pump
- Residence times: 1 second to multi hour
- Wetted materials: Glass, PTFE and PCTFE (stainless steel and hastelloy possible)
- Mixing: Rapid diffusional mixing
- Production volumes: micrograms to kilograms
- Automatic leak detection: Asia can check itself for leaks before running
Asia Modules
Every Asia system includes the Asia Syringe Pump – the most sophisticated flow chemistry pump available.
Due to the modular nature of the system all the Asia modules can be purchased separately, then arranged in any fashion to add new functionalities to an existing system.
The system can advance with the needs and requirements of your evolving chemistry. Click here to find out more about the individual modules (illustrated below).
Reagent Injector
2 Extremely chemically resistant injection valves with sample loops
Pressurized Input Store
This enables the use of air sensitive reagents and eliminates bubble formation when pumping
Chip Climate Controller
This enables glass microreactors to be cooled or heated from -15°C to +150°C
FLLEX
The FLLEX (Flow Liquid Liquid Extraction) module is the flow chemistry equivalent of separatory funnels
Pressure Controller
Automatically pressurizes the reaction up to 20 bar (300psi)
Asia Manager Software
Easy to use for total ‘walk-away’ control of the Asia system
Syringe Pump
2 Extremely chemically resistant continuous flow pumps. This can also be used as the “master” to control certain systems without a PC
Heater (Tube Reactor Adaptor)
This module has different reactor adaptors and enables temperatures up to 250°C
Sampler and Dilutor
This enables on-line reaction analysis by automated sample extraction, dilution and transfer to an analytical system e.g. LCMS or UPLC
Automated Collector
This allows collection of multiple reactions in separate vials or vessels with waste automatically diverted
Examples of Asia Flow Chemistry Benefits
Suzuki reaction with silica supported Pd-catalyst
- Faster reaction and improved selectivity
- Negligible Pd level in product
Hantzsch pyrrole synthesis
- Faster reaction and improved yields
- One-step process
Gold nanoparticle synthesis
- Narrower particle distribution
- Safe corrosive reagent handling
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