Asia Flow Chemistry Examples - Syrris

Examples of Asia flow chemistry benefits:

Suzuki reaction with silica supported Pd-catalyst

• Faster reaction and improved selectivity
• Negligible Pd level in product

Hantzsch pyrrole synthesis

• Faster reaction and improved yields
• One-step process

Gold nanoparticle synthesis

• Narrower particle distribution
• Safe corrosive reagent handling

N-alkylation of a primary amine

• Faster reaction and excellent mono-alkylation selectivity

For examples of flow chemistry performed on Syrris equipment and published in peer reviewed journals please click here.

The list below shows some of the reactions that have been performed on Syrris flow chemistry systems.

Homogeneous catalysis

• Suzuki reaction
• Heck reaction
• Grubbs metathesis

Multicomponent reactions

• Passerini 3CR
• Biginelli 3CR
• Ugi 4CR

Deprotection chemistry

• BOC deprotection
• MOM deprotection and intra epoxide opening
• Ester saponification

Ring formations

• Grubbs metathesis
• Ugi followed by ring closure
• Diels Alder
• 1,3,4 Oxadiazole formation
• Fischer indole synthesis
• 1,3 Thioamidozole formation

Oxidations and reductions

• Borohydride reduction
• Borane reduction of a heterocycle
• Reductive amination
• Dess Martin alcohol oxidation

General syntheses

• Aldol reaction
• Biphasic Schotten-Baumann
• HBTU amide coupling
• Elimination of an alcohol to alkene
• Esterification of an alcohol
• Wittig reaction
• Nucleophilic aromatic substitution
• SN1 reaction
• Mitsunobu reaction