New Asia flow reactor for Electrochemistry launched
The new Asia Flux module combines the best advantages of flow chemistry and electrochemistry enabling tuneable, scalable reactions.
The Asia Flux is ideal for multi-step reactions and applications such as anodic oxidations, cathodic reductions and the synthesis of Phase I drug metabolites and Phase II glutathione adducts.
It allows unique chemical transformations, not possible with other techniques, to be performed quickly and easily, as well as preparative scale electrochemical processes previously limited to batch chemistry, offering ultimate ease of use and reproducibility.
This no tools, compact and easy to use system is compatible with a range of other Asia modules or can be used as a stand-alone unit.
Preparative Microfluidic Electrosynthesis of Drug Metabolites
This paper by Romain Stalder and Gregory P.Roth from Sanford-Burnham Medical Research Institute, USA describes the preparative electrochemical synthesis of phase I and phase II metabolites of a range of commercial drug molecules.
In this study the Flux module is utilised to replicate hepatic oxidation on a range of commercially available drug molecules. Phase I metabolites and Phase II Glutathione adducts were synthesised at the preparative scale (100mg/hr), therefore enabling full structural elucidation of these metabolites to be carried out by NMR (1D and 2D).