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Ammonium formate as a green hydrogen source for clean semi-continuous enzymatic dynamic kinetic resolution of (+/-)-α-methylbenzylamine
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Ammonium formate as a green hydrogen source for clean semi-continuous enzymatic dynamic kinetic resolution of (+/-)-α-methylbenzylamine.
RSC Adv., 2014, 4, 13620
Amanda S. de Miranda, Rodrigo O. M. A. de Souza and Leandro S. M. Miranda
Federal University of Rio de Janeiro, Biocatalysis and Organic Synthesis lab, Chemistry Institute, Av Athos da Silveira Ramos, Rio de Janeiro, Brazil
This paper describes a new, semi-continuous method for the dynamic resolution of (+/-)-α-methylbenzylamine utilising Pd/BaSO4 as racemisation catalyst and ammonium formate as a green reducing agent whilst utilising Novozyme 235 in an immobilised form for the kinetic resolution.
The separation of the chemical and the biocatalysed steps under flow conditions have enabled incompatible conditions for each step to be utilised to generate excellent enantiomeric excess.
Abstract: The chemoenzymatic dynamic kinetic resolution of (+/−)-α-methylbenzylamine under continuous flow conditions in the presence of Pd/BaSO4 as racemization catalyst and ammonium formate as reductant is described. Under the conditions good conversions and excellent enantiomeric excess are reported.