The impact of Flow chemistry has seen this enabling technology being applied to a growing number of applications over the years in modern laboratories. It’s use in the generation of libraries of compounds for screening against a biological target has seen the adoption of this technology being applied in the early drug discovery process to enable the faster exploration to find potential drug candidates.

The use of flow chemistry has many benefits over traditional batch protocols when applied to library generation. Flow chemistry increases the scope of reactions that can be performed even when using automated batch processes and the ability to telescope several operations together enables a more efficient process. The overall improved reproducibility and cost compared to the equivalent manual synthesis has helped to its increased its use in this application.

This presentation looks at how the use of flow chemistry in the generation of compound libraries has enabled the acceleration of early drug discovery projects in the exploration of potential drug candidates. The modern, modular flow chemistry platforms available to chemists along with the development of complex automated experimentation is establishing this technique as a key tool in the drug discovery process.