Crystallization

Crystallization Monitoring and Control with Syrris Atlas HD Crystallization

Crystallization is defined as a process by which a chemical is converted from a liquid solution into a solid crystalline state. Syrris systems offer a range of solutions to the problem of crystallization monitoring and control.

Monitoring

Turbidity probe – see the Atlas HD System with optional Turbidity Probe

FBRM probe – all Atlas systems can be integrated with the Lasentec FBRM probe for particle size analysis

Control

Automation – Intelligent solvent additions and temperature control are made easy with the Atlas Software allowing easy meta-stable zone analysis

Sonocrystallization – crystallization with narrow particle size distribution and polymorph control – See the Sonocrystallisation Applications page or the Atlas HD Sonolab system

Flow chemistry – Excellent control of mixing and temperature leads to narrow particle size distribution. See the Flow Chemistry page.

  • Crystallization is the most common method of formation of pharmaceutical solids
  • Usually aim to achieve goals of high purity and high yield by solely using controlled cooling crystallizations
  • Almost all chemical processes utilize at least one crystallization step (either as key separation mechanism or final product engineering)
  • Crystallization processes are poorly understood and are difficult to control
  • Control of nucleation difficult but is the key to process control
  • Physical form dictates drug product quality and effectiveness
  • Process robustness governs process productivity and economics
A photograph of Atlas HD Crystallization with Sonolab Module
A photograph of the Atlas HD overhead Scorpion Stirrer being clicked into place
A photograph of the Atlas HD clamp and vessel lid

Syrris products offer a range of solutions to the problem of crystallization control and monitoring.

  • Excellent temperature control using sophisticated PID temperature control
  • Metastable zone width determination
  • Crystallize along a turbidity ramp
  • Complete control of nucleation
  • Improved polymorph selectivity
  • Achieve extremely narrow particle distribution
  • Reproducibility
  • Seamless scale up to pilot plant and manufacturing
  • Easy to use drag and drop software

 

See the Atlas Turbidity system or Atlas Sonocrystallisation system page now for more information.

For more information about crystallization, please contact us

Atlas HD - Automated Chemical Synthesis System from Syrris
Atlas HD is the world's most advanced automated chemical synthesis system, designed and built by Syrris. Offering advanced Chemists and Chemical Engineers the ultimate in automation, ease-of-use, flexibility, and touch screen control

Author: Syrris

Category: Applications