Chemistry in Flow

Flow Chemistry reactions performed on Syrris Asia Flow Chemistry systems

The list below shows some of the reactions that have been performed on the Asia Systems. For details on publications that have used Syrris flow chemistry systems, please click here.

Homogeneous Catalysis

  • Suzuki reaction – the organic reaction of an organohalide with an organoborane to give the coupled product using a palladium catalyst and base
  • Heck reaction – the chemical reaction of an unsaturated halide (or triflate) with an alkene in the presence of a base and a palladium catalyst (or palladium nanomaterial-based catalyst) to form a substituted alkene
  • Grubbs metathesis – the exchange of substituents between different olefins (a transalkylidenation)

Multicomponent Reactions

  • Passerini 3CR – a three-component reaction between a carboxylic acid, a carbonyl compound such as a ketone or aldehyde, and an isocyanide, offers direct access to α-hydroxy carboxamides
  • Biginelli 3CR – a multiple-component chemical reaction that creates 3,4-dihydropyrimidin-2(1H)-ones 4 from ethyl acetoacetate 1, an aryl aldehyde (such as benzaldehyde 2), and urea 3
  • Ugi 4CR – a multi-component reaction in organic chemistry involving a ketone or aldehyde, an amine, an isocyanide and a carboxylic acid to form a bis-amide

Deprotection Chemistry

  • BOC deprotection – The formation of Boc-protected amines and amino acids is conducted under either aqueous or anhydrous conditions, by reaction with a base and the anhydride Boc2O
  • MOM deprotection and intra epoxide opening
  • Ester saponification – the process that produces soap, usually from fats and lye

Ring Formations

  • Grubbs metathesis – the exchange of substituents between different olefins (a transalkylidenation)
  • Ugi followed by ring closure
  • Diels Alder – an organic chemical reaction between a conjugated diene and a substituted alkene (commonly termed the dienophile), to form a substituted cyclohexene system
  • 1,3,4 Oxadiazole formation
  • Fischer indole synthesis – a chemical reaction that produces the aromatic heterocycle indole from a substituted phenylhydrazine and an aldehyde or ketone under acidic conditions
  • 1,3 Thioamidozole formation

Oxidations and Reductions

General Syntheses

A close up photograph of Syrris Asia Flow Chemistry modules
A close up photograph of part of the Syrris Asia flow chemistry system
A close up photograph of a Syrris Asia flow chemistry glass microreactor chip
A photograph of an Asia flow chemistry module

Author: Syrris

Category: Applications

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