Scaling Up in Flow

Flow Chemistry scale-up

Flow chemistry systems can not only perform reactions on a small scale for optimization but once the preferred conditions are known, the flow rate can be increased to produce hundreds of grams of product.

Due to reactor volumes of up to 16ml and flow rates of 10 ml/min per input, reaction scales in the order of litres can be synthesized overnight. For example, two pumps, each at 10ml/min will produce 28.8 Litres in a day.

The following nucleophilic aromatic substitution was performed using a Syrris flow chemistry system. The reaction was performed at 150ºC despite the atmospheric boiling point of the solvent being 100ºC using pressurization and, therefore, the superheating capability.

Scaling Up Reaction
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A photograph of a Syrris Asia flow chemistry setup
A photograph of a Syrris Asia flow chemistry system being used for fluorescing chemistry
A photograph of fluorescing chemicals produced by a Syrris Asia flow chemistry system
A close up photograph of a Syrris Asia flow chemistry glass microreactor chip
Asia Flow Chemistry Systems
This video is an overview for Asia, the award winning range of advanced flow chemistry products from Syrris.

Author: Syrris

Category: Applications

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