Power Compensation Calorimetry (PCC) Study

A Power Compensation Calorimetry (PCC) Study of Acetic Anhydride Hydrolysis using Syrris Atlas Calorimeter


The study was performed by a big flavor and perfume manufacturer.

System Configuration

The Atlas Calorimeter system was used in its standard configuration (Figure 1).

Atlas Calorimeter
Figure 1 – The Atlas Calorimeter

Experiment Details

The studied reaction was the hydrolysis of acetic anhydride in presence of a catalytic amount of sulphuric acid.

To an Atlas Jacketed Vessel containing 650 mL water and 2g sulphuric acid, 50ml of acetic anhydride was added during 30 min using the Atlas Syringe Pump.

The experiment was fully automated using Atlas 1.4 Software. The results were analyzed using Atlas Reporting Software.

Hydrolysis of Acetic Anhydride

Data Processing

CSV file “Ac2O_Water-30min-110613” supplied by Firmenich was processed using Atlas Reporting.

The following experiment details were filled in (Figure 2):

Figure 2 - Atlas Calorimetry Application
Figure 2 – Atlas Calorimetry Software Parameters
  • Initial reactor fill volume: 650mL
  • Reactor fluid: Water
  • Added fluid: Acetic anhydride (Note: this fluid type is not available by default and has been added to the fluid list prior to the data analysis)
  • Temperature of the added acetic anhydride was assumed to be 25°C


Atlas Reporting software automatically generated the two following Calorimetry Graphs:

  • Overall Power (Figure 3)
  • Enthalpy (Figure 4)
Figure 3


The Overall Power graph (Figure 3) gives us the following data:

  • Generated Overall Power: +17W
    • This shows that the reaction is exothermic, as expected.

The Enthalpy graph (Figure 4) provides us with the following data:

  • Overall Enthalpy: 11kJ
    • This is the total enthalpy measured during this experiment
  • Addition: 20kJ
    • This is the enthalpy generated by adding a reagent at room temperature to a reaction mixture at a different temperature
  • Reaction Enthalpy: 96kJ
    • This is the enthalpy of the reaction itself, calculated by deducing the enthalpy of addition from the overall enthalpy. This is the data of interest for the chemist


From the Reaction Enthalpy obtained in Atlas Reporting, we can calculate the Heat of Reaction.

Acetic Anhydride Properties:

  • Density: 1.082 g.cm-3
  • Molecular Mass: 102.09 g.mol-1

Heat of Reaction:

?fH°     =          -Reaction Enthalpy / Moles of acetic anhydride

And we know that:

Moles of acetic anhydride       =          Mass of acetic anhydride / Molecular Mass

                                                         =          (Density x Volume) / Molecular Mass


?fH°     =          -(Reaction Enthalpy x Molecular Mass) / (Density x Volume)

      =          -(30.96 x 102.09) / (1.082 x 48)

?fH°     =          -60.86kJ.mol-1

      =          -562kJ.kg-1


The most recent Heat of Reaction (also called Molar Reaction Enthalpy) for the hydrolysis of acetic anhydride listed by the National Institute of Standards and Technology (NIST) is the following:

?fH°     =          -56.6kJ.mol-1

This information can be obtained on their website: http://webbook.nist.gov/cgi/cbook.cgi?ID=C108247&Mask=8

The difference between the Heat of Reaction obtained from the Atlas Calorimeter and the theoretical Heat of Reaction is 4.36kJ.mol-1 (7.5%).


To discuss your reaction calorimetry requirements, please speak to the Chemistry team.

Author: Syrris

Category: Applications