Publication – Little artifices of huge libraries: Secrets of parallel liquid-phase synthesis

Russian Journal of General Chemistry, 2010, 80, (12), 2607–2616

• E. V. Babaev
• Lomonosov Moscow State University, Vorob’evy Gory 1, Moscow, 119991 Russia

This paper describes the potential of flow chemistry performed on Syrris’ Africa flow chemistry system (replaced by Asia) and separation performed using Syrris’ FLLEX (Flow Liquid Liquid EXtraction) technology.

Abstract: Key aspects of differences between liquid-phase parallel synthesis and preparation of a single compound at a time are reviewed. Specific technique and equipment are required to make in a parallel manner such processes as heating (involving MW ovens and flow microreactors), extraction, filtration, and chromatography. Rich illustrations may be useful in educational courses on medicinal and combinatorial chemistry.

The chemistry in this paper was performed on an Africa system (now replaced by Asia). Click here to learn more.