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RSC Adv. 2015, 5, 84350-84355, DOI: 10.1039/C5RA16962C
Patricia B. Momo,a Barbara S. Bellete,a Timothy J. Brocksom,a Rodrigo O. M. A. de Souzab and Kleber T. de Oliveira*a
aUniversidade Federal de Sao Carlos, Departamento de Qu?mica, 13565-905, Sao Carlos, SP, Brazil
bUniversidade Federal do Rio de Janeiro, Instituto de Qu?mica, 22941-909, Rio de Janeiro, Brazil
Researchers from Universidade Federal de Sao Carlos and Universidade Federal de Rio de Janeiro have demonstrated the synthesis of a range of meso-substituted porphyrins under continuous flow conditions. This much-improved method demonstrates the multi-gram scale-up of highly pure porphyrins in a safe, cost-effective, reproducible and robust manner.
Abstract: Porphyrin synthesis by classical methods frequently involves the use of high temperatures, toxic and dangerous reagents yielding the product in very low amounts and with poor scalability. Herein, we have studied the synthesis of meso-substituted porphyrins under continuous flow conditions, thus demonstrating scale-up for the porphyrin synthesis in a safe, cost-competitive, highly pure, reproducible and robust manner.To download the paper click here
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