Facile, Fast and Safe Process Development of Nitration and Bromination Reactions Using Continuous Flow Reactors

Click here to view the full list of Syrris Publications.

Org. Process Res. Dev., 2009, 13 (4), pp 698–705

  • Jacques Pelleter* and Fabrice Renaud
  • AstraZeneca, Centre de recherches, Z. I. La Pompelle, BP1050, 51689 Reims cedex 2, France

In this OPRD paper, chemists at AstraZeneca used Syrris flow chemistry pumps to perform a pyrazole nitration at 0.82 g/h (88% yield, 100% purity).

Abstract: Chemists working in a pilot plant often face safety issues during scale-up operations. With the help of emerging microfluidic applications and microdevices, running hazardous, highly exothermic or potentially unstable reactions can be easily transposed into a safe continuous flow mode. This paper describes how a potentially hazardous pyrazole nitration and the bromination of a variety of electron-rich heteroaromatic substrates were efficiently performed using a cheap and easily available system for bench chemists. Advantages of the continuous flow mode in organic synthetic chemistry will be exemplified by the large-scale production of raw materials under safe, green and reproducible conditions.

To download the paper click here

This paper was published using the Syrris Asia Syringe Pumps.