Multistep Continuous Preparation of Chiral O-Acetyl-cyanohydrins

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Synlett. 2016, 27(2), 262-266, DOI: 10.1055/s-0035-1560644

Aischarya Brahmaa,b, Biagia Musiob, Uliviya Ismayilovac, Nikzad Nikbinb, Sonja B. Kamptmannb, Petra Siegerc, Günter E. Jerominc, Steven V. Leyb, Martina Pohla

  • aaIBG-1: Biotechnology, Jülich, Germany
  • bbDepartment of Chemistry, University of Cambridge, Cambridge
  • cInstitute of Nano- and Biotechnologies (INB), Aachen University of Applied Sciences, Germany

Using Syrris Asia Syringe Pumps researchers at the Dept. of Chemistry (University of Cambridge), IBG-1: Biotechnology (Germany) and INB (Aachen University of Applied Sciences) have demonstrated an enantioselective preparation of O-Acetyl-cyanohydrins in a three-step telescoped continuous process.

The modular components enabled an accurate control of two sequential biotransformations, safe handling of an in situ generated hazardous gas and inline stabilization of products.

This method proved to be advantageous over the batch protocols in terms of reaction time (40 min vs 345 min) and ease of operation, opening up access to reactions which have often been neglected due to safety concerns.

Multistep Continuous Preparation of Chiral O-Acetylcyanohydrins

Abstract: An enantioselective preparation of O-acetyl-cyanohydrins has been accomplished by a three-step telescoped continuous process. The modular components enabled an accurate control of two sequential biotransformations, safe handling of an in situ generated hazardous gas and inline stabilization of products. This method proved to be advantageous over the batch protocols in terms of reaction time (40 min vs 345 min) and ease of operation, opening up access to reactions which have often been neglected due to safety concerns.

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