Syrris in Publications

The Syrris range of batch and flow chemistry products has been used in a number of cutting-edge studies and scientific breakthroughs.  Here is a selection of publications that feature our products.


Green microfluidic synthesis of monodisperse silver nanoparticles via genetic algorithm optimization

Product used: Asia

Using the Syrris Asia system, researchers at the Department of Chemistry (Uppsala University, Sweden) have reported the scalable and green synthesis of monodisperse silver nanoparticles via genetic algorithm optimization.

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N‑Heterocyclic carbene-mediated microfluidic oxidative electrosynthesis of amides from aldehydes

Product used: Asia and the Asia FLUX Module

Using a Syrris Asia flow system and the FLUX continuous electrochemistry module, researchers at the University of Southampton and GlaxoSmithKline have demonstrated a flow process for the N-Heterocyclic carbene-mediated continuous oxidative electrosynthesis of amides from aldehydes.

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C-O bond formation in a microfluidic reactor: high yield SNAr substitution of heteroaryl chlorides

Product used: Asia

Using the Syrris Asia system researchers at the Dept. of Neurology (University of California, US), have reported high yielding SNAr substitutions of Heteroaryl chlorides to form C-O bonds in microfluidic reactors.

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A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems

Product used: Asia

Using the Syrris Asia system researchers at the Dept. of Pharmacy (University of Bari, Italy), have reported a sustainable, versatile, fast and environmentally friendly CBS-asymmetric reduction of aryl and heteroaryl ketones.

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Process intensification for tertiary amine catalyzed glycerol carbonate production

Product used: Asia

In this paper, de Souza’s group present an efficient method for synthesizing glycerol carbonate from glycerol. The chosen synthetic route was first tried and optimized on a small scale using microwave irradiation then transferred onto the Asia Discovery System Advanced for scaling up.

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Multistep continuous preparation of chiral O-Acetylcyanohydrins

Product used: Asia Syringe Pumps

Using Syrris Asia Syringe Pumps researchers at the Dept. of Chemistry (University of Cambridge), IBG-1: Biotechnology (Germany) and INB (Aachen University of Applied Sciences) have demonstrated an enantioselective preparation of O-Acetylcyanohydrin in a three-step telescoped continuous process.

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Exploiting novel process windows for the synthesis of meso-substituted porphyrins under continuous flow conditions

Product used: Asia

Researchers from Universidade Federal de Sao Carlos and Universidade Federal de Rio de Janeiro have demonstrated the synthesis of a range of meso-substituted porphyrins under continuous flow conditions. This much-improved method demonstrates the multi-gram scale-up of highly pure porphyrins in a safe, cost-effective, reproducible and robust manner.

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Continuous flow polymer synthesis toward reproducible large-scale production for efficient bulk heterojunction organic solar cells

Product used: Asia

This paper describes the conversion of a batch process into a continuous flow process for carrying out a complex Stille polycondensation reaction. This process generates high molecular weight polymers for use in tandem solar cells in reproducible small and large scales allowing multi-gram quantities of these photovoltaic polymers to be continuously furnished in high yield and high purity.

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Development of a continuous flow sulfoxide imidation protocol using azide sources under superacidic conditions

Product used: Asia

This paper published by Oliver Kappe’s group from the University of Graz, in collaboration with Lonza and AstraZeneca, focuses on an efficient flow protocol for the synthesis of sulfoximine.

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An Ugi multicomponent azide−alkyne cycloaddition approach for the generation of cyclic peptoids

Product used: Asia

Using a Syrris Asia flow chemistry system researchers at the University of Graz and Universidade de Brasilia have demonstrated a complex, multi-step continuous synthesis of cyclic peptoids using a sequential Ugi multicomponent/Cu-catalysed Azide-Alkyne cycloaddition approach.

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The use of flow chemistry for two-phase dibromocyclopropanation of alkenes

Product used: Asia and Glass Microreactors

Using a Syrris flow system and glass microreactors, researchers at the Norwegian University of Life Sciences and SINTEF Materials and Chemistry have demonstrated a novel method for the dibromo-cyclopropanation of alkenes via a continuous two-phase method.

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Improving the toolbox of bioreductions by the use of continuous flow systems

Product used: Asia

Using the Syrris Asia flow chemistry system researchers at the Universidade Federal do Rio de Janeiro have demonstrated an interesting alternative on the bioreduction of ?-ketoesters by immobilized microorganisms.

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Continuous metal scavenging and coupling to one-pot copper-catalyzed azide-alkyne cycloaddition “click” reaction in flow

Product used: Asia and the Asia FLLEX Module

Using the Syrris Asia FLLEX (Flow Liquid Liquid Extraction) module researchers at the Eindhoven University of Technology have demonstrated an efficient extraction method to continuously remove metal catalysts from an azide-alkyne cycloaddition click reaction in flow.

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Ammonium formate as a green hydrogen source for clean semi-continuous enzymatic dynamic kinetic resolution of (+/-)-α-methylbenzylamine

Product used: Asia

This paper describes a new, semi-continuous method for the dynamic resolution of (+/-)-?-methylbenzylamine utilizing Pd/BaSO4 as racemisation catalyst and ammonium formate as a green reducing agent whilst utilizing Novozyme 235 in an immobilized form for the kinetic resolution.

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Understanding the performance of a microfluidic electrolysis cell for routine organic electrosynthesis

Product used: Asia

This paper aims to close the knowledge gap between microfluidic synthetic organic chemistry and optimized microfluidic organic electrosynthesis. This paper describes the optimization of a previously characterized anodic methoxylation reaction in respect to charge efficiency, selectivity, conversion and product formation rate with the fractional conversion rate being dramatically increased. It is concluded that the Electrochemical cell allows synthesis of several grams per hour with good selectivity.

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Expedient preparation of Nazlinine and a small library of indole alkaloids using flow electrochemistry

Product used: Asia and the Asia FLUX Module

This paper describes the use Syrris’s Asia Flux module to achieve full natural product synthesis of Nazlinine. The building blocks of Nazlinine, along with a library of unnatural ?-methoxyamine congeners, were generated by Flow Electrochemistry very rapidly and in very high yields.

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Accelerating spirocyclic polyketide synthesis using flow chemistry

Product used: Asia

Eight years after its pioneering paper on the multi-step synthesis of the oxomaritidine in flow, Steve Ley’s group publishes a new groundbreaking paper describing the total synthesis of natural products Spirodienal A and Spirangien A. The authors describe the complex synthesis of two key building blocks, where most of the 20+ steps are conducting in continuous flow, then the subsequent reactions leading to the final spirocyclic products.

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Ultrafast polymerization with high throughput and low polydispersity index

Product used: Asia

This paper describes a continuous process for the synthesis of poly(3-hexylthiophene). The authors have improved on the traditional batch Grignard Metathesis polymerization reaction by identifying a solvent which dissolves the catalyst. The optimized liquid flow process has been successfully run on a Syrris Asia system.

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The methoxylation of N-formylpyrrolidine in a microfluidic electrolysis cell for routine synthesis

Product used: Asia

This paper describes the application development of a high-yielding, high-throughput N-formyl-pyrrolidine methoxylation reaction carried out in a flow electrochemical cell. The real throughput of the flow electrochemical cell for this specific reaction is also shown to be at least double that of the nearest competitor and has been measured rather than predicted.

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Synthesis of 4 substituted phthalazin-1(2H) ones from 2 acylbenzoic acids

Product used: Atlas Calorimeter

Using the Syrris Atlas Calorimetry system, researchers in the Process Development and Attribute Sciences groups at Amgen (US) have improved on a key process for controlling the levels of Hydrazine in a Pharmaceutical Intermediate characterized using Power Compensation Calorimetry (PCC).

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Sensitive progesterone determination Using a magnetic particle-based enzyme-linked immunosorbent assay

Product used: Globe (now replaced by Orb)

This publication describes the synthesis, silane functionalization and use of magnetic Iron nanoparticles in combination with enzyme-linked immunosorbent assay (ELISA) to facilitate the hybrid technique of ‘magnetic nanoparticles – ELISA’ for use in the capture of progesterone in numerous types of milk.

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Archived Syrris Publications