Asia Product Knowledge

  • Asia Manager Installation Guide

    This document covers the installation of Asia Manager 1.3.5. and above on a clean computer (with no previous Asia Manager installations).

    1 Installing Asia Manager on a new computer

    Before starting the installation, please ensure that the computer fulfills Syrris PC specifications. You must have full administrator rights in order to install Asia Manager. Please note that other software might interfere with Asia Manager and therefore it is always recommended to perform the installation on a clean new computer.

    1.1 Copy the installer main directory

    Copy the entire directory ‘AsiaManager_version number’ onto the local computer, for example onto the PC Desktop.

    1.2 Install Asia Manager Prerequisites

    In the installer folder, go to “Install 1 – Prerequisites” sub folder and double click on the “setup.exe” icon. If a Windows Security Warning pops-up, click on “Run”.

    This will start a setup wizard. Click “Next” to proceed through the wizard. When requested to acknowledge Terms and Conditions of the use of Asia Manager, click on “I Agree”.

    Once the installation has completed, check that Asia Manager Prerequisites program has been added to the list of programs installed on the computer. If not, do not proceed further and try reinstalling Asia Manager Prerequisites.

    1.3 Install Asia Manager Database

    In the installer folder, go to “Install 2 – Database” sub folder and double click on the “setup.exe” icon. If a Windows Security Warning pops-up, click on “Run”.

    This will start a setup wizard. Click “Next” to proceed through the wizard. When requested to acknowledge Terms and Conditions of the use of Asia Manager, click on “I Agree”.

    Once the installation has completed, check that Asia Manager Database program has been added to the list of programs installed on the computer. If not, do not proceed further and try reinstalling Asia Manager Database.

    1.4 Install Asia Manager

    In the installer folder, go to “Install 3 – Application” sub folder and double click on the “AsiaManager.msi” icon. If a Windows Security Warning pops-up, click on “Run”.

    This will start a setup wizard. Click “Next” to proceed through the wizard. When requested to acknowledge Terms and Conditions of the use of Asia Manager, click on “I Agree”.

    Once the installation has completed, check that Asia Manager Database program has been added to the list of programs installed on the computer. If not try reinstalling Asia Manager Database.

    If you require assistance or further explanation, please contact support@syrris.com.

  • Asia Sampler and Dilutor – Quick Start Guide

    This Technical Note provides instructions on how to install the Asia Sampler and Dilutor (SAD) and how to control it in manual mode and from the software. This is not a User Manual and therefore not all options are covered in this document.

    1. Setting the Asia Sampler and Dilutor

    • Connect the micro mixer chip to the linear connector. The connection can be made on either end
    • Clip the micro mixer chip on the side, next to the Analysis Valve
    • Connect two tubes to the ports labeled “Input” on the valve. Both tubes need to be fitted with filters and plunged into a bottle containing the solvent that will be used for the dilution
    • Connect the Sample Valve to the rest of the flow system (see “From fluidic system” and “To collection” below)

    • Connect the Analysis Valve to the analytical device (see “From pump of the analytical system” and “To detector of the analytical system” below).

    • Using the provided cable, connect the back of the Asia SAD to the analytical device (HPLC, UPLC, LCMS, etc…).
    • Ensure the solvent is HPLC grade and degassed. Prime all the system. Check that there are no bubbles in the syringes and in the tubing.

    2. Controlling the Asia Sampler and Dilutor from the front panel

    To perform a dilution:

    • On the main screen, select RATIO and press the control knob
    • Enter the dilution ratio
    • Press the control knob to validate the dilution ratio entry. The dilution sequence will start immediately: the SAD will take a sample, dilute it to the entered ratio, store the diluted sample in the Analysis Loop and send a contact-closure signal to the analysis equipment. The full sequence is about 2 minute-long

    Overview of the menu options:

    • RATIO: determines the factor by which the reaction sample will be diluted. Example: a RATIO of 76 means that the sample concentration is divided by 76. Entering a RATIO value starts the dilution sequence immediately.
    • PRIME: allows to flush the system with solvent. A prime sequence will fill the syringes with solvent then empty them. The sequence will be repeated the number of times entered in the menu. Use this function to wash the system and to fill all the tubing with solvent.
    • M: gives access to additional control options.
    • LOG: lists all actions performed by the Asia SAD in chronological order.

    3. Controlling the Asia Sampler and Dilutor from Asia Manager software

    Important: To control the Asia SAD via a PC you need Asia Manager software version 1.0.81 or above.

    To use the Asia SAD in an experiment:

    • Ensure the “Sampler Dilutor” is correctly detected in My Modules / Summary
    • In your task / Fluidic Setup, drag and drop the “Sampler Dilutor” component into your fluidic setup. It is usually placed just before the collection point. Design the rest of your fluidic setup as normal
    • In your task / Fluidic Setup, click on the Sampler Dilutor and choose if you want to take samples in the middle of the reaction slug or if you want to take samples at fixed period of time
    • In your task / Experiments, enter all experiment parameters including the dilution ratio for every single experiment
    • Go to Run View and run your list of experiments as normal

    Overview of the Manual Controls options:

    There are two action tabs In Manual Controls for the Sampler Diluter: “Auto” and “Advanced”.

    “Auto” tab options:

    • Prime: flushes the system with solvent. A prime cycle consists in filling the syringes with solvent then emptying them. After entering the number of cycles required click “Start” to start priming. Use this function to wash the system and to fill all the tubing with solvent.
    • Dilute with a ratio of: determines the factor by which the reaction sample will be diluted. Example: a ratio of 76 means that the sample concentration is divided by 76. After entering the ratio value, click “Start” to start the dilution.

    “Advanced” tab options:

    • Initialize: clicking on this button triggers an initializing sequence where the valve is set to its start position and both syringe drives are set to their top position (empty syringes).
    • Send Trigger Pulse: when clicking this button, the Asia SAD sends a contact closure signal to the 3rd party analytical system connected to the SAD.
    • Fill: by clicking on this button, both syringes will be filled
    • Empty: by clicking on this button, both syringes will be emptied.
    • Sample valve position – Load: sets the Sample Valve (top one) to load position i.e. position where the loop is connected to the rest of the fluidic system.
    • Sample valve position – Inject: sets the Sample Valve (top one) to inject position i.e. position where the loop is connected to the valve and the micromixer.
    • Analysis valve position – Load: sets the Analysis Valve (bottom one) to load position i.e. position where the loop is connected to the Sample Valve and to waste.
    • Analysis valve position – Inject: sets the Analysis Valve (bottom one) to inject position i.e. position where the loop is connected to the pump and the detector of the Analytical system.

    4. Controlling the Asia Sampler using 3rd party control

    Important: To control the Asia SAD via 3rd party equipment you will need to use the Asia SAD I/O cable 2400368

    • Connect the bare ends of the cable to your equipment and plug the 8 way DIN plug of the cable into the back of the Asia SAD
    • The table below explains what functions the different wire colors operate

    If you require assistance or further explanation, please contact support@syrris.com.

  • Asia Updater Installation Guide

    This document covers the installation of Asia Updater Manager software and how to link it to the depository of Asia modules firmware.

    1. Installing Asia Updater

    Important Note: Before installing Asia Updater, you must have the latest version of Asia Manager software installed on the computer. If Asia Manager is not installed, please refer to the relevant section of the “Asia Systems and Software Manual”.

    Step 1: Copy the installer directory

    Copy the entire Asia Updater directory on the computer’s Desktop.

    Step 2: Install Asia Updater

    Launch AsiaUpdater_v1.2. This will install Asia Updater. Please note that there is no shortcut created on the desktop.

    Step 3: Create the AsiaNodeUpdatePack depository

    Create a folder named “AsiaNodeUpdatePack” in a known location on the computer hard drive (for example, in Program Files/Syrris/Asia Updater).

    Remember this location: this is where the firmware updates are stored and where any new updates send by Syrris needs to be copied in order to be installed on an Asia Module.

    Step 4: Direct Asia Updater to the AsiaNodeUpdatePack depository

    Asia Updater needs to be pointed towards the location of the AsiaNodeUpdatePack. To do so:

    Go to Program Files/Syrris/Asia Updater and copy the AsiaUpdater.exe.conf file on the computer desktop.

    Open the AsiaUpdater.exe.conf file using Notepad

    Enter the location of the AsiaNodeUpdatePack folder on the fifth line of code after “<add key=”engineeringUpdateLocation” value=” (see picture below, the entered text that points to the location of the AsiaNodeUpdatePack is highlighted in blue).

    Save the modified AsiaUpdater.exe.conf file then copy and paste it back in Program Files/Syrris/Asia Updater. Click “Yes” if you are asked “Do you want to replace the existing file?”

    Step 5: Create a desktop shortcut for Asia Updater

    Create a desktop shortcut pointing to the AsiaUpdater.exe file.

    Asia Updater is ready to use.

    If you require assistance or further explanation, please contact support@syrris.com.

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