Flow chemistry reactions

The list below shows some of the reactions that have been performed on the Asia Systems. For details on publications that have used Syrris flow chemistry systems, please click here.

Homogeneous catalysis

• Suzuki reaction – the organic reaction of an organohalide with an organoborane to give the coupled product using a palladium catalyst and base
• Heck reaction – the chemical reaction of an unsaturated halide (or triflate) with an alkene in the presence of a base and a palladium catalyst (or palladium nanomaterial-based catalyst) to form a substituted alkene
• Grubbs metathesis – the exchange of substituents between different olefins (a transalkylidenation)

Multicomponent reactions

• Passerini 3CR – a three-component reaction between a carboxylic acid, a carbonyl compound such as a ketone or aldehyde, and an isocyanide, offers direct access to α-hydroxy carboxamides
• Biginelli 3CR – a multiple-component chemical reaction that creates 3,4-dihydropyrimidin-2(1H)-ones 4 from ethyl acetoacetate 1, an aryl aldehyde (such as benzaldehyde 2), and urea 3
• Ugi 4CR – a multi-component reaction in organic chemistry involving a ketone or aldehyde, an amine, an isocyanide and a carboxylic acid to form a bis-amide

Deprotection chemistry

• BOC deprotection – The formation of Boc-protected amines and amino acids is conducted under either aqueous or anhydrous conditions, by reaction with a base and the anhydride Boc2O
• MOM deprotection and intra epoxide opening
• Ester saponification – the process that produces soap, usually from fats and lye

Ring formations

• Grubbs metathesis – the exchange of substituents between different olefins (a transalkylidenation)
• Ugi followed by ring closure
• Diels Alder – an organic chemical reaction between a conjugated diene and a substituted alkene (commonly termed the dienophile), to form a substituted cyclohexene system
• 1,3,4 Oxadiazole formation
• Fischer indole synthesis – a chemical reaction that produces the aromatic heterocycle indole from a substituted phenylhydrazine and an aldehyde or ketone under acidic conditions
• 1,3 Thioamidozole formation

Oxidations and reductions

• Borohydride reduction
• Borane reduction of a heterocycle
• Reductive amination – a form of amination that involves the conversion of a carbonyl group to an amine via an intermediate imine
• Dess Martin alcohol oxidation

General syntheses

• Aldol reaction – a means of forming carbon-carbon bonds in organic chemistry.
• Biphasic Schotten-Baumann – a method to synthesize amides from amines and acid chlorides
• HBTU amide coupling – a coupling reagent used in solid phase peptide synthesis
• Elimination of an alcohol to alkene
• Esterification of an alcohol
• Wittig reaction – allows the preparation of an alkene by the reaction of an aldehyde or ketone with the ylide generated from a phosphonium salt
• Nucleophilic aromatic substitution – a substitution reaction in which the nucleophile displaces a good leaving group, such as a halide, on an aromatic ring
• SN1 reaction
• Mitsunobu reaction – allows the conversion of primary and secondary alcohols to esters, phenyl ethers, thioethers and various other compounds